The This Week in Wargaming podcast has a good show that covers Warhammer 40,000 5th Edition. It features, amoung others, Jon “Brimstone” from Warseer.com. The show is a good overview of what is new in 5th edition and the impact of the changes. Also interesting are the opinions on the impact of the changes on tournament play as well as the recent FAQ updates to the various codices. If you wish to skip right to the 40K material forward to about 30 minutes into the show.
Also check out the D6 Generation 40K show.